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International Journal of Neurology Research

Vol. 1, Issue 1, Part A (2019)

Comparison of iron deposition in subcortical structures of brains with Parkinsonian syndromes: A post-mortem 7.0-tesla magnetic resonance study

Author(s):

Jacques De Reuck, Florent Auger, Nicolas Durieux, Claude-Alain Maurage, Vincent Deramecourt, Charlotte Cordonnier, Florence Pasquier, Didier Leys, Regis Bordet

Abstract:
It is not known whether iron (Fe) accumulation is a secondary event in the cascade of the neuronal degeneration rather than the primary cause in different Parkinsonian diseases. The purpose of the present post-mortem study is to evaluate and compare the Fe content in brains of different parkinsonian syndromes with normal control brains. Twenty-six normal brains were compared to 7 with idiopathic Parkinson’s disease (PD), 18 with progressive supranuclear palsy (PSP), 18 with Lewy body dementia (LBD), 6 with corticobasal degeneration (CBD) and 5 with multiple system atrophy (MSA). The hippocampus and 11 subcortical structures were submitted to a 7.0-tesla magnetic resonance imaging (MRI). T2 and T2* sequences were performed: the degree of T2* hypo-intensity, representing the degree of Fe content in the different brain regions, was determined semi-quantitatively. No significant differences in Fe content were observed in all examined structures between normal brains and those with PD, PSP, LBD and CBD. In MSA there was a selective hypo-intensity on T2* sequence in the putamen, reflecting Fe increase, with on the other hand a significant Fe decrease at the level of the dentate nucleus of the cerebellum. The present post-mortem MRI study confirms that the increased hypo-intensity in the putamen is a diagnostic hallmark of MSA, but that also the low Fe content at the level of the dentate nucleus has also to be considered as a valuable indicator of this disease.

Pages: 10-13  |  1500 Views  667 Downloads

How to cite this article:
Jacques De Reuck, Florent Auger, Nicolas Durieux, Claude-Alain Maurage, Vincent Deramecourt, Charlotte Cordonnier, Florence Pasquier, Didier Leys, Regis Bordet. Comparison of iron deposition in subcortical structures of brains with Parkinsonian syndromes: A post-mortem 7.0-tesla magnetic resonance study. Int. J. Neurol. Res. 2019;1(1):10-13. DOI: 10.33545/2664908X.2019.v1.i1a.4